349 matching jobs for “Principal Data Scientist”

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Capital One Financial

Principal Associate, Data Science - Model Risk Office

McLean, Virginia, United States +1 location

Principal Associate, Data Science - Model Risk Office Data is at the center of everything we do. As a startup, we …

Added Oct 27, 2026

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Vertex Pharmaceuticals

Computational Chemistry Principal Research Scientist (Computational Drug Design)

Boston, Massachusetts, United States

Full time
Regular

Pay posted by employer$144,800–$217,200

… programs using a broad range of computational approaches including molecular modeling, cheminformatics, data science, and AI-enabled methods. The right candidate's responsibilities include close interaction with …

Added Oct 18, 2026

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USAA

Data Scientist II (Mid Level) - Pricing and Product Analytics

San Antonio Home Office I +6 locations

Full time
Regular

Pay posted by employer$93,770–$179,240

As a Data Scientist, you will translate business problems into applied statistical, machine learning, simulation, and …

Added Oct 30, 2026

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Labcorp Holdings

Scientist (LCMS)

Singapore, Singapore

Full time
Regular

… on general equipment, including problem identification and resolution. Performs quality control review of data. Informs Study Director, Principal Investigator and/or management of any problems and/or deviations that …

Added Oct 16, 2026

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Vertex Pharmaceuticals

Senior Principal Scientist, Agentic Systems Development for Drug Discovery

Boston, Massachusetts, United States

Full time
Regular

Pay posted by employer$168,000–$252,000

Vertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and …

Added Oct 18, 2026

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Merck (MSD)

Principal Scientist (Scientific Director Level)– Nonclinical Drug Safety

USA - Pennsylvania - West Point +4 locations

Pay posted by employer$176,200–$277,300

… risks associated with therapeutic targets or development candidates using available literature, internal data, and external information. The individual may also lead early development teams, informing on preclinical …

Added Oct 16, 2026

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Pfizer

Principal Scientist, PSSM ARD, GMP Analytics, Stability Strategy & Operations

United States - Connecticut - Groton

Full time
Regular

… decisions and deliver reliable stability information for patients and health authorities. As a Principal Scientist in Analytical Research & Development, GMP Analytics, you will be recognized as a technical expert …

Added Oct 16, 2026

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Capital One Financial

Principal Associate, Data Science - US Card (Upmarket Segments)

McLean, Virginia, United States +2 locations 2 postings

Principal Associate, Data Science - US Card (Upmarket Segments) Data is at the center of everything we do. As a …

Added Oct 27, 2026

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Merck (MSD)

Senior Principal Scientist, Medical Affairs, Global - Head & Neck Cancers

Rahway, New Jersey, United States +1 location

Pay posted by employer$282,200–$444,200

The Sr. Principal Scientist, Global Director of Medical Affairs (GDMA) for Head & Neck Cancers/melanoma, coordinates the …

Added Oct 15, 2026

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Merck (MSD)

Associate Principal Scientist, Regulatory CMC, Synthetic Moities of ADCs & Bioconjugates

USA - Pennsylvania - North Wales (Upper Gwynedd) +1 location

Pay posted by employer$142,400–$224,100

Associate Principal Scientist, Regulatory CMC, Synthetic Moities of ADCs & Bioconjugates This Associate Principal Scientist …

Added Oct 16, 2026

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Johnson & Johnson

Principal Developer, Oncology Data & AI Systems (2 available)

Titusville, New Jersey, United States of America +4 locations

Full time
Regular

Pay posted by employer$117,000–$201,250

… more at https://www.jnj.com/innovative-medicine Johnson and Johnson Innovative Medicine is recruiting a Principal Developer, Oncology Data & AI Systems (2 available positions) to strengthen the AI-ready data foundation …

Added Oct 15, 2026

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Merck (MSD)

Associate Principal Scientist, Combination Product Design Verification (Associate Director Equivalent)

Rahway, New Jersey, United States

Pay posted by employer$142,400–$224,100

… areas and routes of administration, including inhalation, implantation, and injection. The Associate Principal Scientist will provide end‑to‑end technical and project leadership for the definition, integration, and …

Added Oct 16, 2026

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Amgen

Principal Scientist – AI/ML Workflow & Ecosystem Lead (Large Molecule Discovery Informatics)

India - Hyderabad

Full time
Regular

… products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Principal Scientist – AI/ML Workflow & Ecosystem Lead (Large Molecule Discovery Informatics) Live What you will do …

Added Oct 15, 2026

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Labcorp Holdings

Senior Scientist - Immunoassay

Singapore, Singapore

Full time
Regular

… flow cytometry , with the ability to serve as a scientific subject matter expert (SME) for assay design, data interpretation, and regulatory compliance. The successful candidate will lead scientific initiatives, …

Added Oct 16, 2026

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Merck (MSD)

Associate Principal Scientist, Statistical Programming, Late-Stage Oncology (Hybrid)

Rahway, New Jersey, United States +1 location

Pay posted by employer$142,400–$224,100

… Effective knowledge and experience in developing analysis and reporting deliverables for R&D projects (data, analyses, tables, graphics, listings). Leads large and/or complex projects, effectively balances competing …

Added Oct 16, 2026

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Bristol-Myers Squibb

Senior Principal Scientist, Cancer Immunology, Discovery Biology, Oncology Thematic Research Center

Seattle 400 Dexter - WA - US

Full time
Regular

Pay posted by employer$174,020–$210,872

… and a shared commitment to transforming cancer care. Position Responsibilities: In the role as a Senior Principal Scientist within Discovery Biology, the ideal candidate will: Lead matrixed TCE / cancer immunology …

Added Oct 18, 2026

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Johnson & Johnson

Scientist Pharmacometrics Support - Hyderabad

Hyderabad, India

Full time
Regular

Clinical Pharmacology & Pharmacometrics (CPP) Scientist Pharmacometrics Support - Hyderabad Position Summary: The Scientist, Pharmacometrics Support, provides …

Added Oct 16, 2026

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Merck (MSD)

Principal Scientist/Engineer, Drug/Device Combination Products - Device Characterization

Rahway, New Jersey, United States

Pay posted by employer$156,900–$247,000

… the devices’ material and functional properties and attributes. This understanding, combined with extensive data analysis/interpretation, will allow the role to design and develop functional improvements for these …

Added Oct 18, 2026

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Vertex Pharmaceuticals

Senior Principal Scientist, Applied AI & Agentic Systems for Small-Molecule Drug Discovery

Boston, Massachusetts, United States

Full time
Regular

Pay posted by employer$168,000–$252,000

… systems across drug discovery. Working at the intersection of Computational Drug Design, project teams, Data & Methods, and Digital Technology & Engineering, this individual will leverage deep expertise in …

Added Oct 18, 2026

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Gilead Sciences

Sr Scientist, Analytical Ops

Santa Monica, California, United States

Full time
Regular

Pay posted by employer$153,935–$199,210

Senior Scientist, Method Automation ; Analytical Development, Method Development, and Automation Reporting to the Principal …

Added Oct 15, 2026

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Merck (MSD)

Principal Scientist (Scientific Director Level)– Nonclinical Drug Safety

USA - Pennsylvania - West Point +4 more

Pay posted by employer$176,200–$277,300

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Preferred experience · employer excerpt

Experience with biopharmaceutical and small molecule pharmaceutical development and/or discovery.
Experience with regulatory submissions and responses.
Member of pharmaceutical consortia and/or external scientific or professional organizations.

About this opportunity

Original employer description

Job Description

Job Summary:

We are seeking a Discovery Program Leader (DPL) to represent Nonclinical Drug Safety (NDS) on discovery research teams and in scientific and strategic review meetings focused primarily on immunology and oncology. This position requires exceptional leadership, collaboration, and independence, and a passion to work collaboratively across functions and sites to discover novel medicines that improve the lives of patients.

The Discovery Program Leader is responsible for defining and overseeing the NDS strategy for programs in all modalities (including small molecules, peptides, biologics and ADC programs) from Target Identification through to the approval of First-In-Human enabling GLP toxicity studies. They are responsible for 1) providing risk assessments for targets, 2) de-risking strategies for discovery programs and 3) collaborating with NDS staff at other sites to execute on the appropriate studies to support selection of therapeutic targets, and the identification and development of new drug candidates. The DPL may also serve on development teams with responsibility for defining the GLP toxicology study strategy and execution, and for the non-clinical safety sections of regulatory documents that support clinical trials and worldwide marketing authorization.

In this role you will:

Represent NDS on discovery teams and participate in therapeutic area discovery governance committee reviews.

Promote and facilitate creative thinking from target identification/validation through lead optimization in Infectious Disease, Neuroscience, Immunology, Oncology, and/or Cardiometabolic Therapeutic Areas.

Be a “drug creator” and promoter of innovative thinking by influencing both cross-site disease area aligned groups, as well as functional area disciplines.

Identify and assess potential risks associated with therapeutic targets or development candidates using available literature, internal data, and external information.

The individual may also lead early development teams, informing on preclinical studies to support product development.

Qualifications, skills and experience needed:

PhD in relevant field, DVM, MD degree or equivalent.

Minimum 8+ years of demonstrated pharmaceutical industry experience as a non-clinical safety scientist (e.g. Toxicology, Pathology etc.) and/or as non-clinical safety assessment representative to a cross-functional development and/or discovery teams.

Demonstrated ability to successfully navigate cross-functional lines and drive team decision making in a matrix organizational structure.

Highly dedicated, motivated, resilient, and flexible; capable of creative problem solving and delivering on goals and objectives in a timely fashion.

Excellent team player who can work collaboratively with discovery team members from various functions, other DPLs and scientists responsible for study conduct and portfolio management.

Excellent interpersonal skills, able to establish good working relationships within networks of employees of all levels.

Excellent communicator who knows when and how to speak up, and appropriately raise issues to stakeholders and to management.

Preferred experience:

Experience with biopharmaceutical and small molecule pharmaceutical development and/or discovery.

Experience with regulatory submissions and responses.

Member of pharmaceutical consortia and/or external scientific or professional organizations.

Required Skills:

Clinical Safety, Finite Element Analysis (FEA), Good Lab Practices, Immuno-Oncology, Innovative Thinking, Matrix Management, Quality by Design, Regulatory Filings, Regulatory Submissions, Safety Management, Strategic Thinking, Technology Transfer, Toxicology

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

The primary location for this posting is:

USA - Pennsylvania - West Point

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is:

$176,200.00 - $277,300.00

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

Additional location(s): Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location.

Additional location(s) Compensation Information:

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Hybrid

Shift:

1st - Day

Valid Driving License:

Hazardous Material(s):

N/A

Job Posting End Date:

10/30/2026

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

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